Chemical Biology, Biomaterials, Bioanalytical
Many fundamental, yet complex, biological functions are carried out by molecular machineries composed of biopolymers, especially proteins and peptides. Recent advancements in protein and peptide engineering tools have facilitated scientific progress towards a new class of soft materials that merge unique properties of bio- and synthetic polymers.
The Grove lab focuses on design and synthesis of proteins and peptides for a broad variety of applications including assembly of nanostructured materials with tunable morphology and function, biosensing, and drug delivery. Our work is highly interdisciplinary and students will receive training in several areas of chemistry, structural biology, and materials science.
Current projects include:
- Synthesis, assembly, and characterization of protein-polymer conjugates
- Biotemplating of inorganic nanoparticles for optical sensors
- Design of capture agents for glycan sensing
- Design of theranostic nanoparticles
1. Nathan Carter and Tijana Z. Grove: Nanostructured films from hierarchical self-assembly of engineered repeat proteins have anisotropic mechanical properties. 2015, accepted to Biomacromolecules.
2. Xi Geng and Tijana Z. Grove: Repeat-protein mediated synthesis of gold nanoparticles: effect of protein shape on nanoparticle morphology and optical properties. RSC ADVANCES, 2015, 5(3), 2062-2069.
3. Rachael Parker, Ana Y. Mercedes-Camacho, Tijana Z. Grove: Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment. Protein Science, 2014, 23(6), 790-800. Editors choice for June 2014
4. Tijana Z. Grove, Lynne Regan and Aitziber L. Cortajarena; Nanostructured films from engineered repeat proteins, J. R. Soc. Interface, 2013, 10(83):20130051.
5. Tijana Z. Grove and Lynne Regan; New materials from proteins and peptides Curr. Opin. Struct. Biol. 2012, 22:451-6.
- Ralph E. Powe Junior Faculty Enhancement Award, 2013
- Undergraduate Studies, University of Belgrade, 1999
- Ph.D. Iowa State University, 2004
- Postdoctoral Fellow, Yale University, 2006–2011