Research activities have been devoted primarily to the application of principles of small molecular chemistry to problems in biology, with emphasis on the molecular mechanisms of drug metabolism and pharmacological processes, including neurotoxicity and neuroprotection. A major research interest concerns the molecular mechanisms of monoamine oxidase and cytochrome P-450 catalyzed oxidations and the identification of metabolic pathways that may contribute to the biological properties of the substrate molecules.
- Castagnoli, N., Jr., Petzer, J., Steyn, Salome, Castagnoli, K., Chen, J-F., Schwarzschild, M and Van der Schyf, C. (2003) Monoamine oxidase B inhibition and neuroprotection: Studies on selective adenosine A2A receptor antagonists. Neurology, 61 (Supplement 6), S62-S68.
- Bibbiani, F., Oh, J., Petzer, J., Castagnoli, Jr., N., Chen, J-F., Schwarzchild, M. and Chase, T. (2003) A2A antagonist prevents dopamine agonist-induced motor complications in animal models of PD. Exp. Neuro., 184, 285-294.
- Beeler, A., Gadepalli, R., Steyn, Salome, Castagnoli, Jr., N. and Rimoldi, J. (2003) Synthesis and in-vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates. Bioorg. Med. Chem., 11, 5229-5234.
- Bissel, P. and Castagnoli, Jr. , N.(2005) Studies on the cytochrome P450 catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine by 13C NMR. Bioorg. Med. Chem., 13, 2975-2980.
- Frederick, R., Ooms, F., Castagnoli, Jr., N., Petzer, J., Feng, J-F, Schwarzschild, M., Van der Schyf, C., and Wouter, J. (2005) (E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B. Acta Cryst., C61, o531-o532.
- B.S. University of California, 1959
- M.S. University of California, 1961
- Ph.D. University of California, 1964