In contrast to the human genome, the human metabolome is far from complete. In fact, currently, most compounds detected in human samples by untargeted mass spectrometry cannot be structurally identified. Our group aims to uncover this “dark matter” of biochemical space using a combination of organic synthesis, mass spectrometry, data science and culturing. Ultimately, we are interested in discovering new small molecules from vertebrates and their microbiomes that are relevant to human health and disease (biomarkers, therapeutics, etc.).
- Gentry, E. C., Collins, S. L.; Panitchpakdi, M.; Belda-Ferre, P.; Stewart, A. K.; Wang, M.; Jarmusch, A. K. Avila-Pacheco, J.; Plichta, D. R.; Aron, A. T.; Vlamakis, H.; Ananthakrishnan, A. N.; Clish, C. B.; Xavier, R. J.; Baker, E. S.; Patterson, A. D.; Knight, R.; Siegel, D.; Dorrestein, P. C. A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals, under review [https://www.researchsquare.com/article/rs-820302/v1].
- Gentry, E. C.; Rono, L. J.; Hale, M. E.; Matsuura, R.; Knowles, R. R. Enantioselective Synthesis of Pyrroloindolines via Non-Covalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products. J. Am. Chem. Soc. 2018, 140, 3394–3402.
- Zhu, Q.; Gentry, E. C.; Knowles, R. R. Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations. Angew. Chem. Int. Ed. 2016, 55, 9969–9973.
- Pickering Award for Excellence in Teaching, Princeton University, 2014
- B.S. in Chemistry, University of North Carolina at Chapel Hill, 2013
- Ph.D. Chemistry, Princeton University, 2018
- Postdoctoral Researcher, University of California San Diego, 2018-2022