Wei Liu
Location:
3105 Hahn Hall SouthResearch Interests
Addressing standing challenges in synthetic chemistry and biomedical studies.
- Organic Synthesis
- Inorganic Synthesis
- Organometallic Chemistry
- Metal Catalysis
- Biomedical Imaging
1. Trifluoromethylation of alkyl electrophiles with 11C- or 18F-labeled fluoroform for PET applications, Wang, C.†; Dement, P.†; Jana, S.; Hong, J.; Pike, V.; Liu, W. Science, 2025, 390, 1278-1284
2. Enantioselective Difluoromethylation of Unactivated Alkyl Halides via a Formal Nickel(II/IV) Cycle, Zhao, X.,† Yin, L.,† Yang, C.-J., Poore, A.T., Zhang, X., Yachuw, S.C., Wang, C., Wang, X., Guan, H., Krause, J. A., Cheng, M.-J., Tian, S., Liu, W. Nat. Catal. 2026
3. Enantioconvergent Copper-Catalysed Difluoromethylation of Alkyl Halides Ding, D.; Yin, L.; Poore, A. T.; Ho, Y.-S.; Cheng, Y-H; Hsieh, C.-T.; Yachuw, S. C.; Knieser, R. M.; Krause, J. A.; Tian, S.; Cheng, M.-J.; Liu, W. Nat. Catal., 2024, 7, 1372
4. Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis, Ding, D.; Chen, S.; Yin, L.; Ou, W-T.; Krause, J. A.; Cheng, M-J.; Liu, W. Nat. Syn. 2025, 4, 1118–1127
5. Harnessing CO2 Radical Anion-Mediated Electron Transfer for Scalable Copper-Catalyzed Cross-Coupling, Wu, S,; Yang, C.-J.; Cheng, M.-J.; Liu,W. J. Am. Chem. Soc. 2026, 148, 1, 1717–1727
6. Overcoming Copper Reduction Limitation in Asymmetric Substitution: Aryl-Radical-Enabled Enantioconvergent Cyanation of Alkyl Iodides, Chen, S,; Ding, D.; Yin, L.; Krause, J. A.; Liu, W. , J. Am. Chem. Soc., 2024, 146, 46, 31982–31991
7. Highly Enantioselective Dearboxylative Difluoromethylation, Zhao, X.;† Wang, C.;† Yin, L.;†, Liu, W. J. Am. Chem. Soc., 2024, 146, 43, 29297–29304
8. Catalytically Relevant Organocopper(III) Complexes Formed through Aryl-Radical-Enabled Oxidative Addition Yan, W.;† Poore, A.;† Yin, L.;† Carter, S.; Ho, Y.; Wang, C.; Yachuw, S.; Cheng, Y.; Krause, J; Cheng, M.; Zhang, S.; Tian,S.; Liu, W. J. Am. Chem. Soc. 2024, 146, 22, 15176-15185
Ph.D. 2014, Princeton University
B.S. 2008, Peking University
Weiliulab.org